diff --git a/hw/virtio/virtio-mmio.c b/hw/virtio/virtio-mmio.c
index 5952471..1af48a1 100644
--- a/hw/virtio/virtio-mmio.c
+++ b/hw/virtio/virtio-mmio.c
@@ -29,6 +29,7 @@
 #include "qemu/host-utils.h"
 #include "qemu/module.h"
 #include "sysemu/kvm.h"
+#include "sysemu/replay.h"
 #include "hw/virtio/virtio-mmio.h"
 #include "qemu/error-report.h"
 #include "qemu/log.h"
@@ -740,6 +741,11 @@
         proxy->flags &= ~VIRTIO_IOMMIO_FLAG_USE_IOEVENTFD;
     }
 
+    /* fd-based ioevents can't be synchronized in record/replay */
+    if (replay_mode != REPLAY_MODE_NONE) {
+        proxy->flags &= ~VIRTIO_IOMMIO_FLAG_USE_IOEVENTFD;
+    }
+
     if (proxy->legacy) {
         memory_region_init_io(&proxy->iomem, OBJECT(d),
                               &virtio_legacy_mem_ops, proxy,